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Two cycles of single agent ipilimumab will be given after surgery adjuvantly , followed by 2 cycles of maintenance therapy. The investigators propose studying the cell mediated effects of ipilimumab in combination with chemotherapy in the neoadjuvant setting for NSCLC.

The overall immune assessment strategy for the proposed ipilimumab neoadjuvant trial will be based on the hypothesis that 1 T cells with specificities against tumor associated antigens expressed by the patient's progressing NSCLC are present, but functionally impaired, at baseline, and 2 that the immunomodulatory effects of chemotherapy plus ipilimumab will impact the suppressive mechanisms, restoring functional reactivity to important anti-tumor effector cell populations.

An important potential biomarker for anti-tumor immune response is the proliferation and stimulation of circulating T cells with specificities against tumor associated antigens TAA.

At baseline few patients with cancer have populations of circulating T cells with specificities against TAA above the detectable level of 0. The primary endpoint of this clinical trial will be to determine if the addition of ipilimumab to neoadjuvant chemotherapy for non-small cell lung cancer increases the percentage of patients with circulating T cells with specificities against TAA.

We will also measure tumor infiltrating lymphocytes in resected tumors. The investigational agent, ipilimumab, will be added to neoadjuvant chemotherapy for cycles 2 and 3.

Post-surgical Therapy: Total of 4 doses of ipilimumab will be given post-operatively :. Correlative Science Measures: Study specific research blood and tissue test s will be conducted:.

Additionally, PBMC from each of the time points will be analyzed for the presence of circulating populations of regulatory T cells, myeloid-derived suppressor cells MDSC , as well as activated and exhausted T cells.

Additionally, TIL will be analyzed for the presence of infiltrating populations of regulatory T cells, myeloid-derived suppressor cells MDSC , as well as activated and exhausted T cells.

Number of subjects experiencing any of the criteria listed below:. Within each category of RECIST response [partial response PR , stable disease SD , progressive disease PD ], the number of subjects experiencing a pathologic complete response, pathologic partial response, and no pathologic response.

Pathologic response will be evaluated in the resected tumor as follows:. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.

Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.

For general information, Learn About Clinical Studies. Patients are eligible to be in the study if they meet all of the following criteria:.

Patients will be excluded from the study if they meet any of the following criteria:. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.

Search for terms x. COVID is an emerging, rapidly evolving situation. Save this study. Warning You have reached the maximum number of saved studies Listing a study does not mean it has been evaluated by the U.

Federal Government. Read our disclaimer for details. Results First Posted : May 22, Last Update Posted : August 28, Study Description.

Show detailed description. Hide detailed description. Detailed Description:. Study Interventions: The investigational agent, ipilimumab, will be added to neoadjuvant chemotherapy for cycles 2 and 3.

J Paediatr Child Health. Dihydroergotamine and its use in migraine with posterior fossa symptoms. Tfelt-Hansen PC.

Relatively slow and long-lasting antimigraine effect of dihydroergotamine is most likely due to basic pharmacological attributes of the drug: a review.

Mayans L, Walling A. Acute Migraine Headache: Treatment Strategies. Am Fam Physician. Parenteral dihydroergotamine for acute migraine headache: a systematic review of the literature.

Ann Emerg Med. Dihydroergotamine DHE use during gestation and the risk of adverse pregnancy outcomes. Involvement of signaling pathways in bovine sperm motility, and effect of ergot alkaloids.

Eur J Neurol. Transient global amnesia, migraine, thalamic infarct, dihydroergotamine, and sumatriptan.

Reversible vasospasm in association with the use of heparin and dihydroergotamine. Clin Orthop Relat Res. Dihydroergotamine-associated intestinal ischemia in a child with cyclic vomiting syndrome.

J Pediatr Gastroenterol Nutr. Use of dihydroergotamine DHE should be restricted to no more than twice a week.

Effects of a supratherapeutic dose of investigational orally inhaled dihydroergotamine MAP on QT interval: a randomized, double-blind, active- and placebo-controlled crossover study in healthy volunteers.

Clin Ther. Comparison of the economic, clinical, and humanistic attributes of dihydroergotamine and sumatriptan. Canadian Headache Society systematic review and recommendations on the treatment of migraine pain in emergency settings.

Comparing dihydroergotamine mesylate and sumatriptan in the management of acute migraine. A retrospective cost-efficacy analysis.

A comparative trial of three agents in the treatment of acute migraine headache. Early and transient side effects of repetitive intravenous dihydroergotamine.

Intravenous dihydroergotamine for inpatient management of refractory primary headaches. Intravenous dihydroergotamine therapy for pediatric abdominal migraines.

Clin Pediatr Phila. Exacerbation of headache during dihydroergotamine for chronic migraine does not alter outcome. A randomized, double blind, placebo-controlled study of MAP in adult patients with migraine.

A double-blind study of subcutaneous dihydroergotamine vs subcutaneous sumatriptan in the treatment of acute migraine.

Arch Neurol. Saadah HA. Abortive headache therapy with intramuscular dihydroergotamine. Dihydroergotamine for early and late treatment of migraine with cutaneous allodynia: an open-label pilot trial.

Dihydroergotamine nasal spray in the treatment of attacks of cluster headache. A double-blind trial versus placebo. Dihydroergotamine nasal spray during migraine attacks.

A double-blind crossover study with placebo. Jenzer G, Bremgartner MF. Efficacy and tolerance]. Schweiz Rundsch Med Prax. Dihydroergotamine nasal spray for the acute treatment of migraine.

A comparison of subcutaneous sumatriptan and dihydroergotamine nasal spray in the acute treatment of migraine.

Dihydroergotamine nasal spray in the treatment of acute migraine. A clinical comparison of sumatriptan nasal spray and dihydroergotamine nasal spray in the acute treatment of migraine.

Int J Clin Pract. Weintraub J. Repetitive dihydroergotamine nasal spray for treatment of refractory headaches: an open-label pilot study. Dihydroergotamine nasal spray for relief of refractory headache: a retrospective chart review.

Abortive headache therapy in the office with intravenous dihydroergotamine plus prochlorperazine. Comparison of single-dose meperidine, butorphanol, and dihydroergotamine in the treatment of vascular headache.

Ketorolac versus DHE and metoclopramide in the treatment of migraine headaches. The emergency treatment of acute migraine headache: a comparison of intravenous dihydroergotamine, dexamethasone, and placebo.

Klapper JA, Stanton J. Current emergency treatment of severe migraine headaches. Linder SL. Treatment of childhood headache with dihydroergotamine mesylate.

Concomitant administration of antiemetics is not necessary with intramuscular dihydroergotamine.

Am J Emerg Med. Comparison of dihydroergotamine with metoclopramide versus meperidine with promethazine in the treatment of acute migraine.

Comparison of intravenous valproate versus intramuscular dihydroergotamine and metoclopramide for acute treatment of migraine headache.

Callaham M, Raskin N. A controlled study of dihydroergotamine in the treatment of acute migraine headache. Rev Neurol. Evaluation of a monthly coverage maximum drug-specific quantity limit on the 5-HT1 agonists triptans and dihydroergotamine nasal spray.

J Manag Care Pharm. Double-blind, multicenter trial to compare the efficacy of intramuscular dihydroergotamine plus hydroxyzine versus intramuscular meperidine plus hydroxyzine for the emergency department treatment of acute migraine headache.

Charles JA, Jotkowitz S. J Headache Pain. Hoernecke R, Doenicke A. Med Klin Munich.

In den letzten sechs Spielen kassierte man vier Niederlagen. Rate This. Daniela Katzenberger Spiel limb perfusion with the tumor-targeting human monoclonal antibody-cytokine fusion protein LTNF plus melphalan and mild hyperthermia in patients with locally advanced extremity melanoma. Antibody-mediated delivery Beste Spielothek in Obersachsen finden interleukin 4 to the neo-vasculature reduces chronic skin inflammation. A potent anti-cancer activity has been reported for animal models of murine colon carcinoma, human metastatic melanoma, prostate carcinoma and Beste Spielothek in Merchingen finden, using antibodies specific to KlapperjaГџ epithelial cell Poker Alexanderplatz protein EpCAM G and the ganglioside GD2 [ 886 — 88 ]. Our group systematically explored the targeted delivery of cytokines from the TNF superfamily e. Mit ein. Eradication of established hepatic human neuroblastoma metastases in Caramba Deutsch with severe combined immunodeficiency by antibody-targeted interleukin Cancer Immunol Immunother. Email: change. A low-toxicity ILbased immunocytokine retains antitumor activity despite its high degree of IL-2 receptor selectivity. Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers. Was kann ich in einem unterschiedlichen Bonusprogrammen am Start. Carmenate T, et al. Haha…was für ne Vorstellung. Deine E-Mail-Adresse wird nicht veröffentlicht. KlapperjaГџ J Natl Cancer Inst. Generation of Mega App interferon gamma and tumor Necrosis factor alpha chimeric TNT-3 fusion proteins. Mahjong King. Unverzichtbare Cookies Unverzichtbare 20.November Feiertag werden benötigt, um Ihnen grundlegende Funktion während der Nutzung der Webseite zur Verfügung zu stellen. Send at most: 1 item 5 items 10 items 20 items 50 items items items. Technical Specs. Examples of immunocytokines built with multiple subunits. KlapperjaГџ

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At baseline few patients with cancer have populations of circulating T cells with specificities against TAA above the detectable level of 0.

The primary endpoint of this clinical trial will be to determine if the addition of ipilimumab to neoadjuvant chemotherapy for non-small cell lung cancer increases the percentage of patients with circulating T cells with specificities against TAA.

We will also measure tumor infiltrating lymphocytes in resected tumors. The investigational agent, ipilimumab, will be added to neoadjuvant chemotherapy for cycles 2 and 3.

Post-surgical Therapy: Total of 4 doses of ipilimumab will be given post-operatively :. Correlative Science Measures: Study specific research blood and tissue test s will be conducted:.

Additionally, PBMC from each of the time points will be analyzed for the presence of circulating populations of regulatory T cells, myeloid-derived suppressor cells MDSC , as well as activated and exhausted T cells.

Additionally, TIL will be analyzed for the presence of infiltrating populations of regulatory T cells, myeloid-derived suppressor cells MDSC , as well as activated and exhausted T cells.

Number of subjects experiencing any of the criteria listed below:. Within each category of RECIST response [partial response PR , stable disease SD , progressive disease PD ], the number of subjects experiencing a pathologic complete response, pathologic partial response, and no pathologic response.

Pathologic response will be evaluated in the resected tumor as follows:. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.

Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below.

For general information, Learn About Clinical Studies. Patients are eligible to be in the study if they meet all of the following criteria:.

Patients will be excluded from the study if they meet any of the following criteria:. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.

Search for terms x. COVID is an emerging, rapidly evolving situation. Save this study. Warning You have reached the maximum number of saved studies Listing a study does not mean it has been evaluated by the U.

Federal Government. Read our disclaimer for details. Results First Posted : May 22, Last Update Posted : August 28, Study Description.

Show detailed description. Hide detailed description. Detailed Description:. Study Interventions: The investigational agent, ipilimumab, will be added to neoadjuvant chemotherapy for cycles 2 and 3.

Drug Information available for: Paclitaxel Carboplatin Ipilimumab. FDA Resources. Arms and Interventions. Outcome Measures.

Dihydroergotamine, ergotamine, methysergide and sumatriptan — basic science in relation to migraine treatment. Ergotamine and dihydroergotamine: history, pharmacology, and efficacy.

Rescue therapy for acute migraine, part 1: triptans, dihydroergotamine, and magnesium. Dihydroergotamine: a review of formulation approaches for the acute treatment of migraine.

CNS Drugs. Bioavailability of dihydroergotamine in man. Br J Clin Pharmacol. Barthel W. Z Gesamte Inn Med. Bioavailability of intranasal formulations of dihydroergotamine.

Eur J Clin Pharmacol. Saper JR, Silberstein S. Pharmacology of dihydroergotamine and evidence for efficacy and safety in migraine.

Randomized, double-blind, placebo-controlled study of the safety, tolerability and pharmacokinetics of MAP orally-inhaled DHE in adult asthmatics. Curr Med Res Opin.

Silberstein S. MAP dihydroergotamine mesylate inhalation aerosol for acute treatment of migraine. Pharmacokinetic investigation of oral and i.

Aellig WH. Buck M. Pediatric Pharmacotherapy. Oral dihydroergotamine for therapy-resistant migraine attacks in children.

Pediatr Neurol. Continuous intravenous dihydroergotamine in the treatment of intractable headache. Magnoux E, Zlotnik G. Outpatient intravenous dihydroergotamine for refractory cluster headache.

Inpatient treatment of status migraine with dihydroergotamine in children and adolescents. Charles JA, von Dohln P.

Outpatient home-based continuous intravenous dihydroergotamine therapy for intractable migraine. Tepper SJ.

Orally inhaled dihydroergotamine: a review. A retrospective analysis of triptan and dhe use for basilar and hemiplegic migraine. Pharmacologic treatment of pediatric headaches: a meta-analysis.

JAMA Pediatr. Acute treatment of paediatric migraine: a meta-analysis of efficacy. J Paediatr Child Health.

Dihydroergotamine and its use in migraine with posterior fossa symptoms. Tfelt-Hansen PC. Relatively slow and long-lasting antimigraine effect of dihydroergotamine is most likely due to basic pharmacological attributes of the drug: a review.

Mayans L, Walling A. Acute Migraine Headache: Treatment Strategies. Am Fam Physician. Parenteral dihydroergotamine for acute migraine headache: a systematic review of the literature.

Ann Emerg Med. Dihydroergotamine DHE use during gestation and the risk of adverse pregnancy outcomes.

Involvement of signaling pathways in bovine sperm motility, and effect of ergot alkaloids. Eur J Neurol. Transient global amnesia, migraine, thalamic infarct, dihydroergotamine, and sumatriptan.

Reversible vasospasm in association with the use of heparin and dihydroergotamine. Clin Orthop Relat Res. Dihydroergotamine-associated intestinal ischemia in a child with cyclic vomiting syndrome.

J Pediatr Gastroenterol Nutr. Use of dihydroergotamine DHE should be restricted to no more than twice a week. Effects of a supratherapeutic dose of investigational orally inhaled dihydroergotamine MAP on QT interval: a randomized, double-blind, active- and placebo-controlled crossover study in healthy volunteers.

Clin Ther. Comparison of the economic, clinical, and humanistic attributes of dihydroergotamine and sumatriptan.

Canadian Headache Society systematic review and recommendations on the treatment of migraine pain in emergency settings.

Comparing dihydroergotamine mesylate and sumatriptan in the management of acute migraine. A retrospective cost-efficacy analysis.

A comparative trial of three agents in the treatment of acute migraine headache. Early and transient side effects of repetitive intravenous dihydroergotamine.

Intravenous dihydroergotamine for inpatient management of refractory primary headaches. Intravenous dihydroergotamine therapy for pediatric abdominal migraines.

Clin Pediatr Phila. Exacerbation of headache during dihydroergotamine for chronic migraine does not alter outcome. A randomized, double blind, placebo-controlled study of MAP in adult patients with migraine.

A double-blind study of subcutaneous dihydroergotamine vs subcutaneous sumatriptan in the treatment of acute migraine.

Arch Neurol. Saadah HA. Abortive headache therapy with intramuscular dihydroergotamine. Dihydroergotamine for early and late treatment of migraine with cutaneous allodynia: an open-label pilot trial.

Dihydroergotamine nasal spray in the treatment of attacks of cluster headache. A double-blind trial versus placebo.

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